2. Signaling Pathways
  3. Epigenetics
  4. Epigenetic Reader Domain
  5. BRD4 Isoform
  6. BRD4 Degrader

BRD4 Degrader

BRD4 Degraders (6):

Cat. No. Product Name Effect Purity
  • HY-163638
    BRD4 degrader-1
    		Degrader
    BRD4 degrader-1 (Compound ML 1-50) is a monovalent and covalent molecular glue BRD4 degrader. BRD4 degrader-1 targets DCAF16 (E3 ligase) and degrades both the long and short isoforms of BRD4 in cells.
  • HY-107425A
    cis-MZ 1
    		Degrader
    cis-MZ 1 is a negative control of MZ 1 (HY-107425). cis-MZ 1 is a PROTAC.html" class="link-product" target="_blank">PROTAC targeting to BRD4.
  • HY-143328
    PROTAC BRD4 Degrader-17
    		Degrader
    PROTAC BRD4 Degrader-17 (compound 13i) is a potent PROTAC BRD4 Degrader, with IC50 values of 29.54 nM (BRD4 (BD1)) and 3.82 nM (BRD4 (BD2)). PROTAC BRD4 Degrader-17 significantly attenuates G2/M progression associated Cyclin B1 expression. PROTAC BRD4 Degrader-17 significantly induces apoptosis in MV-4-11 cells.
  • HY-162240
    SJH1-51B
    		Degrader
    SJH1-51B is a potent PROTAC degrader of BRD4. SJH1-51B has anti-tumor effect.
  • HY-161368
    BRD-SF2
    		Degrader
    BRD-SF2 is a BRD4-targeted PROTAC degrader (DC50: 17.2 μM) (Blue: VHL ligand, black: linker, pink: BRD4 ligand).
  • HY-158331
    Gal-ARV-771
    		Degrader
    Gal-ARV-771, PROTAC prodrug, is a gal modified ARV-771 (HY-100972). Gal-ARV-771 can be activated in SA-β-Gal-expressed cancer senescent cells to release ARV-771. Gal-ARV-771 induces selective degradation of BRD4 protein by the ubiquitin-proteasome pathway in senescent cells. Gal-ARV-771 promotes apoptosis of senescent cancer cells.